Twenty years later, Giovanni is mysteriously murdered and Cosimo and Lorenzo try to secretly investigate his death. The Medici's candidate gets elected, which ensures to the bank of the Medici an unparalleled economic power. Cosimo falls in love with her but is then forced to leave her and marry Contessina de Bardi, a political marriage arranged by Giovanni and Contessina's father. In Rome, Cosimo, fascinated by the beauty of ancient architectures and art, meets Donatello and one of his models Bianca.

The election of a new Pope is about to take place and Giovanni sends his sons Cosimo and Lorenzo to Rome in order to encourage the election of a Pope close to his family. He has a plan to increase his family power by making an agreement with the Church of Rome.

Giovanni de' Medici is a rich banker who also represents one of the most important political forces of Florence's Signoria. The series is broadcast in 190 countries worldwide, including on Netflix in the United States, Canada, the UK, Ireland and India, and on SBS in Australia. According to Italian ratings compiler Auditel, the broadcast of the first episode attracted a record 8.04 million viewers. The series reached between four and eight million viewers on original airings.

A third, which completes the story of Lorenzo, premiered on Rai 1 in Italy on 2 December 2019. The second season, titled Medici: The Magnificent, takes place 35 years later and tells the story of Cosimo's grandson Lorenzo de' Medici (known as the Magnificent). His son Cosimo de' Medici succeeds him as head of the family bank, the richest bank of Europe at that time, and fights to preserve his power in Florence.

The first season, titled Medici: Masters of Florence, takes place in 1429, the year Giovanni de' Medici, head of the family, died. Each season follows the events of a particular moment of the family history exploring the political and artistic landscape of Renaissance Italy. The series follows the Medici family, bankers of the Pope, during Renaissance Florence. The series premiered in Italy on Rai 1 on 18 October 2016. The series was produced by Italian companies Lux Vide and Rai Fiction, in collaboration with Frank Spotnitz's Big Light Productions. Medici ( Italian: I Medici) is a historical drama created by Frank Spotnitz and Nicholas Meyer.

Cast of medici season 1